Mareike D. Hoffmann
Papers
1
Total Citations
103
H-Index
1
About
Dr. Mareike D. Hoffmann is a pioneering metabolic engineer whose work has fundamentally advanced the sustainable production of essential nutrients. Her research centers on the synthetic biology of lipids and the engineering of microbial cell factories for high-value compounds. Her most impactful contribution is the development of an exclusively acyl-CoA-dependent pathway for the biosynthesis of ω3-very long chain polyunsaturated fatty acids (VLCPUFA), such as DHA and EPA. This seminal 2008 work, cited over 100 times, provided a groundbreaking alternative to traditional fish oil extraction, addressing the critical decline of ocean fish stocks. By elegantly bypassing the need for acyl-ACP intermediates, Hoffmann’s pathway enabled efficient, scalable production in heterologous hosts. This achievement not only demonstrates her deep expertise in lipid biochemistry and metabolic flux analysis but also holds profound implications for human nutrition and global food security. Her work remains a cornerstone for researchers seeking to engineer sustainable sources of these brain-essential fatty acids.
Research Focus
Key Achievements
Top Papers
- 1