Marcel van der Weiden
Papers
1
Total Citations
57
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1
About
Marcel van der Weiden is a molecular biologist whose research centers on vascular biology and the molecular mechanisms underlying tumor angiogenesis, with a particular focus on gliomas. His most cited work, a 2004 study on the differential expression of splicing variants of the human caldesmon gene (CALD1) in glioma neovascularization versus normal brain microvasculature, has garnered 57 citations. This seminal contribution revealed how alternative splicing of CALD1 produces distinct protein isoforms that are uniquely upregulated in the blood vessels feeding aggressive brain tumors, offering a potential biomarker for glioma progression and a target for anti-angiogenic therapy. By elucidating the molecular differences between tumor-associated and normal brain vasculature, van der Weiden’s research has advanced our understanding of how cancer hijacks vascular development. His work underscores the importance of splicing regulation in disease and provides a foundation for developing more precise diagnostic and therapeutic strategies against glioblastoma, one of the most lethal brain cancers.
Research Focus
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Top Papers
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