Makoto Sano
Papers
1
Total Citations
12
H-Index
1
About
Makoto Sano is a pathologist and molecular biologist whose research centers on the molecular diagnostics of breast cancer, with a particular focus on the HER2/neu oncogene. His most cited work, a 2004 study, pioneered the use of laser-assisted microdissection to precisely compare HER2 mRNA amplification with standard immunohistochemistry (IHC) in human breast cancer. This investigation was critical in validating the correlation between HER2 protein overexpression (score 3+) and mRNA amplification, providing a more rigorous molecular foundation for identifying patients who would benefit from trastuzumab (Herceptin) therapy. By demonstrating that IHC results could be reliably confirmed at the genetic level, Sano’s research helped refine diagnostic accuracy, ensuring that only patients with true HER2-driven tumors receive targeted therapy. With 12 citations, this study remains a touchstone for translational pathology, bridging the gap between routine clinical staining and molecular analysis. Sano’s contributions have directly impacted breast cancer treatment protocols, offering a model for integrating microdissection techniques into precision oncology. His work exemplifies how careful molecular validation can improve prognostic outcomes and therapeutic decision-making in cancer care.
Research Focus
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Top Papers
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