Mahavir Singh
Papers
1
Total Citations
69
H-Index
1
About
Mahavir Singh is a leading figure in mycobacterial metabolism, with a particular focus on the survival mechanisms of *Mycobacterium tuberculosis*. His research centers on the biosynthesis of cysteine, a critical pathway that not only provides a building block for proteins but also supplies reduced thiols essential for oxidative defense—a process especially vital during the bacterium’s dormant state. In his highly cited 2008 study (69 citations), Singh demonstrated that CysM, previously annotated as a cysteine synthase, actually functions as an *O*-phosphoserine sulfhydrylase, revealing a key alternative route for cysteine production. This discovery reshaped the understanding of sulfur metabolism in *M. tuberculosis* and highlighted potential vulnerabilities for drug targeting. By illuminating how the pathogen sustains itself under stress, Singh’s work has provided foundational insights into the metabolic adaptations that enable *M. tuberculosis* to persist in the host, making his contributions invaluable to researchers developing novel anti-tuberculosis therapies.
Research Focus
Key Achievements
Top Papers
- 1