M.A. Neben-Wittich
Papers
4
Total Citations
92
H-Index
4
About
Dr. M.A. Neben-Wittich is a leading clinical researcher in head and neck oncology, with a focused expertise in de-escalation strategies for human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (OPSCC). Her major contributions center on proving that reducing the intensity of adjuvant radiation and chemotherapy—after transoral robotic surgery (TORS)—can maintain excellent cure rates while dramatically lowering long-term toxic effects. Her landmark Phase III trial, MC1675 (53 citations), formally evaluated this de-escalated adjuvant radiation therapy (DART) approach against standard treatment. Complementing this, her Phase II study MC1273 (19 citations) provided critical evidence on improved swallow function and quality of life with dose-reduced chemoradiation. Dr. Neben-Wittich has also advanced the understanding of postoperative circulating tumor HPV DNA (ctHPVDNA) kinetics, establishing this biomarker’s role in early response monitoring. Her work, including analyses of 30-day morbidity after TORS (16 citations), has directly shaped modern, less-toxic treatment paradigms for HPV-positive oropharyngeal cancer, offering patients a path to cure with fewer lifelong side effects.
Research Focus
Key Achievements
Top Papers
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