Luc Selig

Papers

Total Citations

147

H-Index

About

Luc Selig has been a driving force in the development of high-throughput methodologies for mapping the interactome, the complete set of protein-protein interactions within a cell. His most influential work, the seminal 2000 paper "Genome‐wide protein interaction maps using two‐hybrid systems," has garnered 147 citations and established the yeast two-hybrid (Y2H) system as the gold standard for genome-wide exploratory analysis. Selig’s contributions lie in demonstrating how automated sequence technology could be harnessed to render functional biology—once limited to single-gene studies—amenable to genomic scale. By championing Y2H over other techniques, he helped pioneer the systematic, large-scale detection of protein interactions, providing a foundational blueprint for subsequent interactome projects in organisms from yeast to humans. His work has been instrumental in shifting biological research from reductionist to network-based approaches, enabling scientists to visualize and understand the complex molecular wiring that underlies cellular function. For students and researchers entering the field of systems biology, Selig’s legacy is a testament to the power of marrying computational automation with classical genetic tools to unlock the hidden language of proteins.