Lihong Du
Papers
2
Total Citations
45
H-Index
2
About
Lihong Du is a distinguished bioanalytical chemist whose research focuses on advancing liquid chromatography–tandem mass spectrometry (LC-MS/MS) methodologies for precise quantification of pharmaceutical compounds in biological matrices. Du’s major contributions lie in developing high-throughput, sensitive, and reliable assays that enable accurate pharmacokinetic and metabolic studies. Notably, Du pioneered a high turbulence liquid chromatography (HTLC) online extraction method coupled with MS/MS for the simultaneous determination of suberoylanilide hydroxamic acid (SAHA) and its two metabolites in human serum, a technique that has garnered 43 citations for its robustness and efficiency in handling complex biological samples. This work has been instrumental in supporting the clinical development of SAHA, a histone deacetylase inhibitor used in cancer therapy. Additionally, Du designed a flexible LC-MS/MS assay for quantifying telcagepant in human plasma, demonstrating versatility in adapting to diverse drug candidates. With a total citation count exceeding 45, Du’s methodologies are widely recognized for enhancing throughput and accuracy in drug metabolism and pharmacokinetics (DMPK) studies. Their achievements underscore a commitment to bridging analytical innovation and therapeutic development, making Du a key figure in bioanalytical science.
Research Focus
Key Achievements
Top Papers
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