Klaus Frueh
Papers
1
Total Citations
257
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1
About
Klaus Frueh is a pioneering virologist whose research has fundamentally shaped our understanding of human cytomegalovirus (HCMV) biology and host-pathogen interactions. His landmark 1999 study, cited over 250 times, introduced the first viral DNA microarray for HCMV, enabling simultaneous expression profiling of nearly all open reading frames in this complex herpesvirus. This groundbreaking tool revolutionized the field by allowing researchers to map viral gene expression kinetics and assess drug sensitivity with unprecedented precision. Beyond this seminal work, Frueh has made major contributions to elucidating how HCMV manipulates the host immune system, particularly through viral evasion of MHC class I antigen presentation. His research has uncovered critical mechanisms by which HCMV establishes lifelong latency and reactivation, providing fundamental insights into viral pathogenesis. With a career spanning decades, Frueh’s work has been instrumental in advancing our understanding of herpesvirus biology, influencing both basic virology and the development of antiviral strategies. His innovative use of genomic technologies continues to inspire new approaches in viral research and therapeutic development.
Research Focus
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