Khaled Machaca
Papers
1
Total Citations
31
H-Index
1
About
Khaled Machaca is a leading figure in reproductive and cellular physiology, whose research centers on the molecular mechanisms governing calcium (Ca²⁺) signaling during oocyte maturation and fertilization. His major contributions have elucidated how eggs acquire the competence to generate the precise, species-specific Ca²⁺ transients that are essential for egg activation—including the block to polyspermy and the resumption of meiosis. In his highly cited 2009 work, Machaca demonstrated that kinase-dependent regulation of inositol 1,4,5-trisphosphate receptor-mediated Ca²⁺ release is a critical switch during oocyte maturation, ensuring the proper spatial and temporal dynamics of the fertilization signal. With over 30 citations, this study has become a cornerstone for understanding the temporal encoding of egg activation events. Beyond this seminal paper, his broader body of work has significantly advanced our knowledge of ion channel regulation and Ca²⁺ homeostasis in reproductive biology. Machaca’s research not only provides fundamental insights into fertility and developmental biology but also holds implications for assisted reproductive technologies and the treatment of infertility.
Research Focus
Key Achievements
Top Papers
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