Jun Kawaguchi
Papers
1
Total Citations
8
H-Index
1
About
Jun Kawaguchi’s research centers on perioperative immunomodulation, with a specific focus on how anesthetic techniques influence immune function in cancer surgery patients. His major contribution lies in demonstrating that ketamine, when used as an adjunct to total intravenous anesthesia, can modulate natural killer cell cytotoxicity (NKCC)—a critical immune defense mechanism against tumor recurrence. In his most cited work, a randomized pilot trial involving patients undergoing minimally invasive radical prostatectomy, Kawaguchi showed that ketamine administration reduced postoperative NKCC suppression, suggesting a potential strategy to improve cancer outcomes. This study, published in 2020, has garnered 8 citations, reflecting growing interest in anesthetic-driven immunomodulation. Kawaguchi’s work bridges anesthesiology and oncology, offering a novel perspective on how surgical stress and anesthetic choices may impact long-term prognosis. His findings have implications for designing safer perioperative protocols, particularly for cancer patients, and highlight the need for larger trials to validate these immunomodulatory effects. By addressing a previously underexplored link between anesthesia and immune surveillance, Kawaguchi has opened a promising avenue for improving surgical oncology care.
Research Focus
Key Achievements
Top Papers
- 1