Joshua C. Kwekel
Papers
1
Total Citations
384
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1
About
Joshua C. Kwekel has made significant contributions to the field of cancer biomarker discovery, with a primary focus on prostate cancer. His most impactful work, the 2003 study "Antibody microarray profiling of human prostate cancer sera," has garnered 384 citations, establishing him as a key figure in the development of high-throughput proteomic techniques. In this landmark paper, Kwekel and his colleagues pioneered a practical strategy for serum protein profiling using antibody microarrays, enabling the simultaneous screening of multiple proteins from small sample volumes. By comparing protein abundances in serum from 33 prostate cancer patients and 20 healthy controls, they successfully identified potential biomarkers that could distinguish malignant from benign conditions. This work not only advanced the methodology for cancer diagnostics but also laid the groundwork for future studies in personalized medicine. Kwekel’s research exemplifies the power of integrating innovative laboratory techniques with clinical applications, offering a scalable approach to early cancer detection. His contributions continue to influence the development of non-invasive diagnostic tools, making his work essential reading for students and researchers in oncology and proteomics.
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