Josephine Bunch

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About

Josephine Bunch is a leading figure in mass spectrometry imaging and biomedical analysis, with a career defined by pioneering work in spatial proteomics and clinical diagnostics. Her research bridges the gap between advanced analytical chemistry and real-world medical applications, particularly through the development of methods to map molecular distributions directly from tissue sections. A standout contribution is her work on dried blood spot proteomics, exemplified by her 2013 paper on surface extraction of endogenous proteins coupled with automated sample preparation and mass spectrometry analysis—a highly cited study (69 citations) that demonstrated how dried blood spots, traditionally used for small molecules, could be a rich source of protein biomarkers. This innovation has profound implications for neonatal screening, remote patient monitoring, and large-scale epidemiological studies. Beyond this, Bunch has driven the application of matrix-assisted laser desorption/ionization (MALDI) imaging to complex biological systems, enabling researchers to visualize proteins, lipids, and metabolites in situ. Her impact is reflected in a growing citation record and her leadership in national facilities, where she has shaped the infrastructure for multi-modal imaging. Bunch’s work not only advances fundamental understanding of disease mechanisms but also provides practical tools for precision medicine, making her a transformative voice in the field.