Jonathan C. Trinidad
Papers
1
Total Citations
8
H-Index
1
About
Jonathan C. Trinidad is a biochemist and mass spectrometrist whose research centers on the functional characterization of enzymes, particularly glycosidases, and the development of innovative analytical tools for glycobiology. His most notable contribution is the development of a high-throughput mass-spectrometry-based assay for identifying the biochemical functions of putative glycosidases, published in 2017. This work addresses a critical limitation of traditional glycosidase assays, which rely on bulky ultraviolet or fluorescent tags that can interfere with substrate recognition and limit substrate scope. By leveraging mass spectrometry, Trinidad’s method allows for label-free, direct detection of enzymatic activity on native carbohydrate substrates, enabling broader and more physiologically relevant substrate characterization. This assay has been cited 8 times and represents a significant methodological advance for researchers studying carbohydrate-active enzymes. Trinidad’s work exemplifies the integration of analytical chemistry and enzymology, providing the glycobiology community with a powerful tool to deorphanize uncharacterized glycosidases and accelerate the discovery of new enzymatic functions.
Research Focus
Key Achievements
Top Papers
- 1