Jefferson Moulds
Papers
1
Total Citations
55
H-Index
1
About
Jefferson Moulds is a cancer geneticist whose research focuses on the molecular underpinnings of hereditary breast cancer, particularly the role of the ATM gene. His most influential work, a 2003 study on ATM missense mutations, demonstrated that these genetic variants are surprisingly frequent in patients with breast cancer, challenging prior assumptions about their rarity. With 55 citations, this paper has become a foundational reference for understanding how subtle changes in DNA repair genes can elevate cancer risk. Moulds’ contributions have helped bridge the gap between basic genetic discovery and clinical risk assessment, offering new avenues for identifying high-risk individuals. His work underscores the complexity of cancer genetics, moving beyond well-known genes like BRCA to reveal the broader landscape of susceptibility. By highlighting the prevalence of ATM mutations, Moulds has shaped subsequent screening strategies and therapeutic approaches, making his research essential reading for students and clinicians alike. His findings continue to influence studies on DNA damage response pathways and their implications for personalized medicine.
Research Focus
Key Achievements
Top Papers
- 1ATM missense mutations are frequent inpatients with breast cancer55 citations · 2003