Hugues Matile
Papers
1
Total Citations
13
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1
About
Hugues Matile is a prominent figure in cardiovascular proteomics, best known for pioneering multidimensional approaches to lipoprotein analysis. His major contributions center on developing innovative techniques to profile the complex protein composition of plasma lipoproteins, which are critical in the pathogenesis of cardiovascular disease. In his landmark 2011 study, cited over 13 times, Matile introduced a powerful method combining size exclusion chromatography with reverse-phase protein arrays. This technique enables the simultaneous separation and quantification of multiple apolipoproteins across different lipoprotein particles, offering unprecedented resolution of their molecular diversity. By revealing how specific proteins associate with distinct lipoprotein classes, Matile’s work has deepened our understanding of lipid transport and inflammation in atherosclerosis. His methodological advances have provided researchers with robust tools for biomarker discovery and risk stratification. Beyond this seminal paper, Matile’s research continues to influence the field, bridging analytical chemistry and clinical cardiology. His dedication to refining proteomic workflows has made him a key contributor to the study of lipoprotein biology and its implications for human health.
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