Holger Nef

Universitätsklinikum Gießen und Marburg, Justus-Liebig-Universität Gießen

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About

Holger Nef is a leading interventional cardiologist whose work is at the forefront of merging robotics with complex coronary interventions. His primary research focuses on advancing robotic-assisted percutaneous coronary intervention (R-PCI) and refining techniques for treating heavily calcified coronary lesions. Dr. Nef’s major contributions include pioneering the first-ever fully robotically assisted intravascular lithotripsy (IVL) for heavily calcified left main stenosis, a landmark case that demonstrates the feasibility of combining robotic precision with advanced debulking technologies. He has also systematically investigated the predictors and necessity of manual support during R-PCI, providing crucial data to optimize procedural safety and workflow. With his most cited work accumulating over 10 citations, Dr. Nef is actively shaping the evidence base for robotic intervention. His 2022 case report, in particular, stands as a notable achievement, showcasing a novel, minimally invasive approach for one of the most challenging scenarios in interventional cardiology. For students and researchers, Dr. Nef’s work represents the cutting edge of how automation and advanced device technology are converging to improve outcomes for patients with complex coronary artery disease.