Harry LeVine
Papers
1
Total Citations
64
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1
About
Harry LeVine is a prominent neuroscientist whose research has centered on the molecular mechanisms of Alzheimer’s disease, particularly the aggregation and toxicity of amyloid-beta (Aβ) peptides. His major contributions lie in elucidating the pathways by which Aβ assembles into neurotoxic oligomers and fibrils, a critical step in disease progression. In his highly cited 2009 study, "Clioquinol and other hydroxyquinoline derivatives inhibit Aβ(1–42) oligomer assembly," LeVine demonstrated that metal-chelating compounds like clioquinol can disrupt early Aβ aggregation, offering a potential therapeutic strategy. This work, with 64 citations, underscores his impact on understanding metal ion involvement in Alzheimer’s pathology. Beyond this, LeVine has developed innovative assays for detecting Aβ oligomers and has explored the role of oxidative stress in neurodegeneration. His research has been instrumental in shaping the field’s approach to targeting protein misfolding, and his findings continue to inform drug development efforts aimed at halting or slowing Alzheimer’s disease.
Research Focus
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Top Papers
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