Papers
1
Total Citations
71
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1
About
Habib Derbali is a leading researcher in cardiovascular pathophysiology, with a primary focus on valvular heart disease and lipid metabolism. His most-cited work, "Increased Biglycan in Aortic Valve Stenosis Leads to the Overexpression of Phospholipid Transfer Protein via Toll-Like Receptor 2" (2010, 71 citations), represents a landmark contribution to understanding the molecular mechanisms driving aortic valve stenosis. In this study, Derbali demonstrated how the proteoglycan biglycan, elevated in stenotic valves, activates Toll-Like Receptor 2 signaling to upregulate phospholipid transfer protein, thereby promoting lipid accumulation and valve calcification. This discovery provided a novel mechanistic link between extracellular matrix remodeling and inflammatory lipid pathways in valve disease. Derbali’s research has significant implications for identifying therapeutic targets to slow or prevent aortic stenosis progression, a condition affecting millions worldwide. His work is widely cited by cardiovascular biologists and clinicians, underscoring its impact on both basic science and translational medicine. Derbali continues to advance the field by exploring how innate immune receptors and lipid transporters interact in cardiovascular pathology, offering new insights into disease mechanisms and potential interventions.
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