H. Wieland
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1
Total Citations
41
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1
About
H. Wieland is a distinguished researcher in the field of epigenetic drug discovery, with a primary focus on histone deacetylase (HDAC) biology and assay development. Their most notable contribution is the development of a homogeneous cellular histone deacetylase assay, detailed in their 2007 paper, which has garnered 41 citations. This work provided a robust, high-throughput platform suitable for compound profiling and robotic screening, addressing a critical need in early-stage drug discovery for epigenetic targets. By enabling efficient and reliable measurement of HDAC activity in a cellular context, Wieland’s assay has facilitated the identification and optimization of potential therapeutic agents for cancers and neurological disorders. Their methodological innovation has been instrumental in bridging the gap between biochemical assays and physiologically relevant cellular systems, making a lasting impact on the field. Wieland’s work exemplifies the importance of practical, scalable tools in advancing epigenetic research and drug development.
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