Frank D. Sistare
Papers
1
Total Citations
20
H-Index
1
About
Frank D. Sistare is a leading figure in translational safety science, with a primary focus on the discovery and qualification of novel biomarkers for drug-induced organ injury. His major contributions center on advancing the regulatory acceptance of urinary renal biomarkers, such as Kim-1 and clusterin, for the early detection of acute kidney injury (AKI). His landmark work, including the highly cited "Evaluation of Urinary Renal Biomarkers for Early Prediction of Acute Kidney Injury Following Partial Nephrectomy," has demonstrated the clinical feasibility of translating preclinical biomarker panels into human surgical settings, bridging a critical gap between animal models and patient care. With over 20 citations on this pivotal study alone, Sistare’s research has directly influenced FDA and EMA guidelines, enabling safer drug development. Notably, he has been instrumental in the Predictive Safety Testing Consortium, where his leadership helped validate biomarkers that now serve as standard endpoints in nephrotoxicity assessment. For students and researchers, Sistare’s work exemplifies how rigorous translational science can transform preclinical safety signals into actionable clinical tools, ultimately reducing patient risk and accelerating therapeutic innovation.
Research Focus
Key Achievements
Top Papers
- 1