Douglas S. Rehder
Papers
2
Total Citations
92
H-Index
2
About
Douglas S. Rehder is a leading figure in clinical mass spectrometry, with his research primarily focused on developing high-throughput, quantitative methods for analyzing protein biomarkers critical to endocrinology and bone health. His major contributions lie in advancing mass spectrometric immunoassays (MSIA) for clinical diagnostics, moving beyond traditional immunological methods to achieve greater specificity and throughput. His most cited work, a 2014 paper on a parallel workflow for high-throughput quantitative analysis of human insulin-like growth factor 1 (IGF1), has garnered 52 citations. This study addressed a pressing need for reliable MS-based detection of IGF1, a key biomarker for managing growth hormone disorders, by enabling analysis of over 1,000 samples per day. In a subsequent highly cited study (40 citations), Rehder applied advanced mass spectrometry to define the gamma-carboxylation and fragmentation of osteocalcin in human serum. This work clarified the circulating proteoforms of osteocalcin, a specific measure of bone turnover, challenging prior immunological assumptions and providing a more precise molecular foundation for bone health assessment. Through these contributions, Rehder has significantly advanced the clinical utility and reliability of mass spectrometry in protein biomarker analysis.
Research Focus
Key Achievements
Top Papers
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