Derris S Appleton
Papers
1
Total Citations
10
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1
About
Derris S Appleton is a clinical researcher whose work focuses on the diagnosis and management of endocrine causes of hypertension, particularly primary hyperaldosteronism. His major contributions center on identifying and characterizing adrenal microadenomas and unilateral adrenal hyperplasia as often-overlooked, curable causes of refractory hypertension. Appleton’s most cited paper, “Primary hyperaldosteronism due to adrenal microadenoma: a curable cause of refractory hypertension” (2008), with 10 citations, highlights the diagnostic challenges of this condition—noting that classic signs like hypokalaemic alkalosis, high plasma aldosterone, or a visible adenoma on imaging may all be absent. Through detailed case studies, he demonstrated that resistant hypertension can be successfully treated when these subtle adrenal abnormalities are identified. His work has helped shift clinical awareness toward more thorough screening in difficult-to-control hypertension, emphasizing that curable endocrine causes are more common than previously recognized. Appleton’s research remains a valuable reference for endocrinologists and hypertension specialists seeking to improve diagnostic accuracy and patient outcomes in primary aldosteronism.
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