Dea Shahinas
Papers
1
Total Citations
90
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1
About
Dea Shahinas is a leading researcher in infectious disease pharmacology, with a primary focus on antimalarial drug discovery and the molecular mechanisms of drug resistance. Her most cited work, "A Repurposing Strategy Identifies Novel Synergistic Inhibitors of *Plasmodium falciparum* Heat Shock Protein 90" (2010, 90 citations), exemplifies her innovative approach to combating malaria—a disease responsible for 3 million deaths annually. In this landmark study, Shahinas performed a robotic high-throughput screen of 4,000 small molecules from natural compound and pharmacologically active libraries, identifying novel synergistic inhibitors that target the parasite's heat shock protein 90. This repurposing strategy not only revealed promising new drug candidates but also addressed the critical challenge of widespread antimalarial drug resistance. Her contributions have provided a well-defined molecular target and a practical pathway for developing combination therapies. With over 90 citations, this work has significantly influenced the field of parasitology and drug development, demonstrating Shahinas’s impact as a researcher dedicated to translating basic science into actionable therapeutic solutions.
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