David S. Schrump

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About

David S. Schrump is a leading thoracic surgeon-oncologist whose research focuses on the molecular biology and precision therapy of esophageal and lung cancers. His major contributions center on developing novel strategies to overcome therapeutic resistance and improve patient outcomes. In a landmark 2018 study, Schrump pioneered the use of metabolomic and BH3 profiling to assess esophageal cancers, providing new methods for predicting response to neoadjuvant chemoradiotherapy. This work, which has garnered 8 citations, offers a pathway to personalized treatment by identifying which patients will benefit from aggressive therapy versus those who may require alternative approaches. Schrump’s broader impact is reflected in his extensive body of work on epigenetic therapies and cancer stem cell biology, with his most cited papers collectively cited over 1,000 times. As Chief of the Thoracic Surgery Branch at the National Cancer Institute, he has also been instrumental in advancing clinical trials for novel immunotherapies and targeted agents. His research has been recognized with numerous awards, including the NIH Director’s Award, and his work continues to shape the landscape of precision oncology for thoracic malignancies.