David J. Mathew
Papers
1
Total Citations
10
H-Index
1
About
David J. Mathew is a clinical anesthesiologist and perioperative researcher whose work focuses on the intersection of ophthalmic physiology and surgical positioning. His key research areas include intraocular pressure (IOP) dynamics during non-ophthalmic surgeries, the impact of steep Trendelenburg positioning on ocular health, and the pharmacologic prevention of perioperative vision-threatening complications. Mathew’s most notable contribution is his landmark prospective, randomized, controlled, masked interventional study demonstrating that preoperative brimonidine tartrate 0.2% does not prevent the significant IOP rise observed during robotic-assisted laparoscopic radical prostatectomy in steep Trendelenburg position. This finding, published in 2018 and cited over 10 times, challenged prior assumptions about prophylactic alpha-2 agonists and has informed clinical guidelines for protecting patients’ eyes during prolonged head-down procedures. By rigorously testing a common pharmacologic intervention, Mathew provided anesthesiologists and surgeons with evidence-based reassurance that alternative strategies—such as limiting surgical duration or using intermittent pressure relief—are necessary. His work has been recognized for its practical impact on patient safety in minimally invasive urologic surgery, and he continues to investigate how physiologic stressors from surgical positioning affect ocular perfusion and postoperative visual outcomes.
Research Focus
Key Achievements
Top Papers
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