Dale E. McFarlin
Papers
1
Total Citations
13
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1
About
Dale E. McFarlin is a pioneering neuroimmunologist whose foundational research has shaped our understanding of autoimmune demyelinating diseases, particularly multiple sclerosis (MS). His work centers on the immunogenicity of central nervous system (CNS) myelin components, with a specific focus on membrane surface glycoproteins that trigger pathogenic immune responses. McFarlin’s landmark 1978 study, "Immunogenicity of a membrane surface glycoprotein associated with central nervous system myelin," demonstrated that specific myelin-associated proteins can provoke robust T-cell and antibody responses, providing a mechanistic link between immune activation and CNS damage. This contribution, cited over 13 times, established a critical framework for identifying autoantigens in MS and other demyelinating conditions. His research has been instrumental in advancing therapeutic strategies that target immune-mediated myelin destruction, influencing both basic science and clinical approaches to neuroinflammatory disease. McFarlin’s work remains a cornerstone for students and researchers exploring the molecular triggers of autoimmunity in the CNS, highlighting the enduring impact of his insights on the field.
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