Costanza M. Donati

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About

Costanza M. Donati is a leading researcher in pediatric radiation oncology, with a specialized focus on advancing stereotactic radiosurgery for childhood cancers. Her work centers on the application of CyberKnife technology—a robotic, image-guided system that delivers ultra-precise radiation—to address the unique challenges of treating pediatric patients, whose developing tissues are highly sensitive to radiation and at elevated risk for long-term toxicities. In her seminal 2025 narrative review, Donati systematically examined treatment approaches and outcomes for pediatric tumors, demonstrating how CyberKnife’s sub-millimeter accuracy can minimize damage to healthy organs while effectively targeting malignancies. This work, already garnering early citations, has helped establish a framework for integrating non-invasive, hypofractionated regimens into pediatric protocols, reducing the need for anesthesia and shortening treatment durations. Her contributions are particularly impactful in the context of rare pediatric cancers, where conventional radiotherapy often poses prohibitive risks. By bridging the gap between adult stereotactic radiosurgery and pediatric-specific needs, Donati is shaping a new standard of care that prioritizes both efficacy and long-term quality of life for young patients.