Christine M. Hulette

Papers

Total Citations

H-Index

About

Christine M. Hulette is a distinguished neuropathologist whose research has centered on the diagnosis and characterization of progressive multifocal leukoencephalopathy (PML), a devastating demyelinating disease of the central nervous system caused by the JC virus. Her major contributions lie in refining the surgical pathological diagnosis of PML, emphasizing the critical importance of identifying pathognomonic histological features in cerebral biopsy tissue. She advanced this field by pioneering the use of in situ hybridization with a biotinylated JC virus DNA probe, automated on a Histomatic Code-On slide stainer, to enhance diagnostic accuracy—especially when only small tissue fragments are available. Her seminal works from 1991, each garnering 17 and 14 citations respectively, have provided foundational protocols that remain essential for clinicians and researchers confronting PML, particularly in immunocompromised patients. Through these efforts, Hulette has significantly improved the reliability of PML diagnosis, enabling more timely and precise interventions. Her meticulous approach to neuropathological techniques underscores her lasting impact on the understanding and detection of viral-induced neurological disorders.