Christelle Borel
Papers
1
Total Citations
363
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1
About
Christelle Borel is a leading molecular geneticist whose research bridges functional genomics, regulatory RNA biology, and the genetic underpinnings of complex human diseases. Her most cited work, a landmark 2007 study with 363 citations, uncovered a pivotal mechanism by which a single-nucleotide polymorphism (SNP) in the 3′ untranslated region of the AGTR1 gene creates a differential binding site for microRNA-155, encoded on chromosome 21. This discovery provided the first clear demonstration of how a common genetic variant can alter miRNA–mRNA interactions to influence blood pressure regulation and related phenotypes, offering a paradigm for understanding functional SNPs in human disease. Borel’s contributions have significantly advanced the field of post-transcriptional gene regulation, particularly in cardiovascular and developmental contexts. Her research is distinguished by its integration of computational prediction with rigorous experimental validation, setting a standard for studies of miRNA target polymorphisms. With her work cited extensively in genetics, cardiovascular biology, and RNA biology, Borel continues to shape our understanding of how subtle genetic variations translate into phenotypic diversity and disease susceptibility.
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