Charissa Lam

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About

Charissa Lam is a developmental neuroscientist whose research focuses on the mechanisms of brain injury and repair following perinatal stroke. Her work centers on understanding how the developing brain responds to focal ischemic injury, particularly through the lens of reactive astrogliosis and its long-term implications for neurodevelopmental outcomes. Lam’s most-cited study, “Perilesional Gliosis Is Associated with Outcome after Perinatal Stroke” (2021), provides critical insights into how glial scarring around the injury site correlates with functional prognosis in infants. By linking the extent of perilesional gliosis to motor and cognitive outcomes, her research offers a potential biomarker for predicting disability severity and guiding early intervention strategies. Though early in her career, Lam’s contributions are already shaping how clinicians and scientists conceptualize brain plasticity and repair in the context of early-life stroke. Her work underscores the importance of glial biology in neonatal brain injury and opens new avenues for therapeutic targeting of reactive astrocytes to improve long-term outcomes for children with hemiplegic cerebral palsy.