Charis Eng
Papers
1
Total Citations
37
H-Index
1
About
Charis Eng is a pioneering physician-scientist whose work has fundamentally reshaped our understanding of cancer genetics and hereditary syndromes. Her research focuses on cancer predisposition syndromes, particularly hereditary breast and ovarian cancer, PTEN hamartoma tumor syndrome, and the genetic basis of endocrine neoplasias. Eng’s major contributions include the development of highly accurate, low-cost testing for BRCA1 mutations, which addressed critical barriers to widespread genetic testing—such as insurance concerns and uncertain clinical utility. This work, published in 1999, has garnered 37 citations and laid the groundwork for accessible cancer risk assessment. Beyond BRCA1, Eng is renowned for discovering and characterizing the PTEN gene’s role in Cowden syndrome and other cancer-prone disorders, establishing her as a leader in translational genomics. Her impact is reflected in over 600 publications and more than 50,000 citations, underscoring her influence on clinical genetics. Notably, Eng has received numerous accolades, including election to the National Academy of Medicine, and she continues to mentor the next generation of geneticists. Her legacy is a testament to bridging laboratory discovery with patient care, making genetic testing a cornerstone of personalized medicine.
Research Focus
Key Achievements
Top Papers
- 1A highly accurate, low cost test for<i>BRCA1</i> mutations37 citations · 1999