Chang Woo Lee

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About

Chang Woo Lee is a leading surgical oncologist whose research focuses on the optimal management of human papillomavirus (HPV)-related oropharyngeal cancer, particularly in balancing oncological control with functional preservation. His major contributions center on comparative effectiveness studies between transoral robotic surgery (TORS) and primary radiotherapy for p16-positive oropharyngeal squamous cell carcinoma. In his landmark 2025 study, Lee systematically analyzed oncological and functional outcomes for T1-2 N0-1 patients, providing critical evidence that helps guide treatment selection in this rapidly evolving field. By directly comparing TORS with neck dissection (with or without adjuvant therapy) against primary radiotherapy, his work addresses a key clinical dilemma: how to maximize cure rates while minimizing long-term swallowing and speech morbidity. This research has immediate relevance for multidisciplinary tumor boards and has already garnered attention from head and neck surgeons and radiation oncologists worldwide. Lee’s contributions are particularly valuable as they help define which patients benefit most from surgical versus non-surgical approaches, ultimately advancing personalized treatment strategies for HPV-positive oropharyngeal cancer.