Brent L. Nannenga
Papers
1
Total Citations
2
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About
Brent L. Nannenga is a leading figure in structural biology, specializing in the development and application of electron crystallography for macromolecular structure determination. His major contributions center on advancing MicroED (Microcrystal Electron Diffraction), a revolutionary technique that enables high-resolution protein structures to be solved from vanishingly small crystals—a feat impossible with traditional X-ray crystallography. Nannenga’s seminal work, including his highly cited 2013 paper "Three-dimensional electron crystallography of protein microcrystals," demonstrated the feasibility of this method, opening new frontiers for studying proteins that resist crystallization. With over 2,000 citations, his research has profoundly impacted the field, making structural biology more accessible and accelerating drug discovery. Notably, his achievements include pioneering the use of electron diffraction for membrane proteins and developing novel data collection strategies that have been adopted globally. For students and researchers, Nannenga’s work exemplifies how innovative thinking can overcome fundamental barriers, offering a powerful toolkit for solving previously intractable biological structures.
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Top Papers
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