Ayako Negishi
Papers
1
Total Citations
35
H-Index
1
About
Dr. Ayako Negishi is a translational researcher whose work focuses on improving outcomes for patients with pancreatic cancer, one of the most lethal malignancies. Her key research areas include biomarker discovery, pharmacogenomics, and personalized oncology. In her most-cited study, "Survival Prediction for Pancreatic Cancer Patients Receiving Gemcitabine Treatment" (2010, 35 citations), Dr. Negishi addressed a critical clinical challenge: while gemcitabine monotherapy remains the standard of care for advanced pancreatic cancer, patient responses are highly variable, and many derive little benefit. Using liquid chromatography-mass spectrometry (LC-MS), she systematically compared baseline metabolite profiles to identify novel biomarkers capable of predicting overall survival. This work laid the groundwork for more individualized treatment strategies, aiming to spare non-responders from ineffective therapy while guiding clinicians toward more effective alternatives. Her contributions highlight the power of integrating analytical chemistry with clinical oncology to move beyond one-size-fits-all treatment. Dr. Negishi’s research continues to influence the pursuit of precision medicine in gastrointestinal cancers, offering hope for better risk stratification and improved patient outcomes in a disease with historically poor prognosis.
Research Focus
Key Achievements
Top Papers
- 1