Alvin Shrier
Papers
1
Total Citations
96
H-Index
1
About
Alvin Shrier is a leading cardiac electrophysiologist whose research has fundamentally advanced our understanding of the molecular mechanisms underlying cardiac arrhythmias and sudden death. His work primarily focuses on the biophysics and pharmacology of ion channels, particularly the HERG (KCNH2) potassium channel, which is critical for normal heart rhythm. Shrier’s major contributions include elucidating the role of the co-chaperone FKBP38 in promoting HERG channel trafficking, a landmark study published in 2007 that has garnered 96 citations. This discovery provided key insights into the pathogenesis of Long QT Syndrome, a disorder that predisposes individuals to life-threatening ventricular arrhythmias. By connecting molecular chaperone dysfunction to channelopathies, Shrier has bridged basic biophysics with clinical cardiology. His work has been instrumental in shaping therapeutic strategies for arrhythmia management. With a career spanning decades, Shrier remains a pivotal figure in cardiac research, mentoring the next generation of scientists while continuing to unravel the complex signaling networks that govern cardiac excitability.
Research Focus
Key Achievements
Top Papers
- 1Co-chaperone FKBP38 Promotes HERG Trafficking96 citations · 2007