ROLE OF THE KALLIKREIN-KININ RECEPTOR SYSTEM IN PROSTATIC PROLIFERATIVE PROCESSES

摘要

<p>In prostatic hyperplasia (PH) and prostate cancer (PC), changes in major cell functions are manifested by impairments in the expression levels of genes and their products, in transmissions, etc. The regulatory components of the renin-angiotensin and kallikrein-kinin systems are known to play a vital role in ensuring the homeostasis of tissue, including that of prostatic tissue. It is promising to elucidate the specific features of these processes in the diagnosis of PC. Polyfocal prostate puncture biopsy specimens were examined in 15 males with PC and 15 with benign PH (BPH). Immunohistochemical reactions were made in an automatic robotic apparatus. B1 expression was ascertained to be fully absent in patients with BPH. Malignant acini and prostatic intraepithelial neoplastic foci showed a specific reaction with anti-B1 antibodies in the glandular epithelium. B2 expression was seen in the stroma in both BPH and PC irrespective of their stage and total Gleason scores. The findings of the pattern of B1 expression suggest that it may be used as a marker for PC.</p>