Robot assisted retinal vein cannulation in an <i>in vivo</i> porcine retinal vein occlusion model

摘要

Purpose To evaluate the feasibility of robot assisted retinal vein cannulation for retinal vein occlusion. Methods Prospective experimental study performed in in vivo porcine eyes. A standard three port pars plana vitrectomy was followed by laser induced branch retinal vein occlusion. Consequently, a retinal vein cannulation with the help of a surgical robot and a micro‐needle was performed. Complete success was defined as a stable intravenous position of the needle tip confirmed by blood washout for at least 3 min. Secondary outcomes were the occurrence of intraoperative complications and technical failures. Results Cannulation was successful in 15 out of 18 eyes with a complete success rate (duration of infusion of more than 3 min) of 73.3% after exclusion of 2 eyes from analysis due to failure in establishing a blood clot. There were no technical failures regarding the robotic device. The intravessel injections of ocriplasmin in 2 out of 2 eyes led to a clot dissolution. In a subset of 5 eyes, a second cannulation attempt at the border of the optic disc resulted in a stable intravessel position and infusion during 361.8 (±138.5) seconds. Conclusions Robot assisted retinal vein cannulation with prolonged infusion time is technically feasible. Human experiments are required to analyze the clinical benefit of this new therapy.