Comment on the LACC Trial Investigating Early-stage Cervical Cancer by the Uterus Commission of the Study Group for Gynecologic Oncology (AGO) and the Study Group for Gynecologic Endoscopy (AGE) of the German Society for Gynecology and Obstetrics (DGGG)

摘要

The results of the LACC trial (Laparoscopic Approach to Cervical Cancer) were first presented in a lecture given at the 49th conference of the Society of Gynecologic Oncology (SGO) held in New Orleans on March 24-27, 2018 [1]. The primary objective of this international randomized phase III multicenter study was to compare disease-free survival (DFS) rates of women who underwent laparoscopic or robotic radical hysterectomy with the DFS of women who had abdominal radical hysterectomy (TLRH/TRRH versus TARH). Secondary goals of the study included rates of re-currence, treatment-associated morbidity, overall survival, cost effectiveness, and quality of life. The trial was designed as a noninferiority study of the laparoscopic treatment arm compared to the abdominal standard-of-care arm, with a follow-up of 4.5 years and a sample size of 740 patients. Patients with primary squamous cell carcinoma, adenocarcinoma or adeno-squamous carcinoma of the uterine cervix with FIGO stage IA1 (with lymphovascular space invasion, LVSI), IA2 or IB1 disease were included in the study.