Benefit of Robotic Assistance in Comparing Outcomes of Minimally Invasive Versus Open Radical Prostatectomy

摘要

toxicity by Morel at al 2 , also cited by Deenen et al and already discussed, sex had unfortunately not been taken into account as a separate risk factor, and the sex of the patients experiencing toxicity had not been revealed.Importantly, the female patient alluded to by Deenen et al who experienced lethal toxicity was homozygous for DPYD*2.In conclusion, we thank Deenen et al for their detailed analysis of our data and for pointing out possible alternative explanations.The additional data presented here do not support their hypotheses but they provide additional support to our main findings of low positive predictive value for DPYD*2A genotyping and an intriguing interaction between DPYD genetics and sex for the development of FUrelated toxicity.Together with our additional observation that the patient's genetic background determines to some extent the type of toxicity, value of detailed prospective studies is emphasized and warrants additional investigation into genome-wide determinants as well as nongenetic causes of toxicity.